Sunday, July 20, 2008

Asbestos Cancer

What is asbestos?
Asbestos is the name given to a group of minerals that occur naturally in the environment as bundles of fibers and can be separated into thin, durable threads. These fibers are resistant to heat, fire, and chemicals and do not conduct electricity. For these reasons, asbestos has been widely used in many industries.
There are two subgroups of asbestos: chrysotile, which has curly fibers and is in the serpentine family of minerals; and amphibole asbestos, which has straight, needle-like fibers and includes actinolite, tremolite, anthophyllite, crocidolite, and amosite asbestos. Chrysotile asbestos is the form that has been used predominantly in commercial applications worldwide (1, 2).
How is asbestos used?
Asbestos was mined and used commercially in North America beginning in the late 1800s. Its use increased greatly during World War II (3, 4). Since then, asbestos has been used in many industries. For example, the building and construction industry has used it for strengthening cement and plastics as well as for insulation, roofing, fireproofing, and sound absorption. The shipbuilding industry has used asbestos to insulate boilers, steampipes, and hot water pipes. The automotive industry uses asbestos in vehicle brakeshoes and clutch pads. Asbestos has also been used in ceiling and floor tile; paints, coatings, and adhesives; and plastics. In addition, asbestos has been found in vermiculite-containing consumer garden products and some talc-containing crayons.
In the late 1970s, the U.S. Consumer Product Safety Commission (CPSC) banned the use of asbestos in wallboard patching compounds and gas fireplaces because the asbestos fibers in these products could be released into the environment during use. Additionally, in 1979, manufacturers of electric hairdryers voluntarily stopped using asbestos in their products. In 1989, the U.S. Environmental Protection Agency (EPA) banned all new uses of asbestos; uses established prior to 1989 are still allowed. The EPA also established regulations that require school systems to inspect for damaged asbestos and to eliminate or reduce the exposure to occupants by removing the asbestos or encasing it (2).
In June 2000, the CPSC concluded that the risk of children’s exposure to asbestos fibers in crayons was extremely low (1). However, the U.S. manufacturers of these crayons agreed to eliminate talc from their products. In August 2000, the EPA responded to reports it received about the adverse human health effects associated with exposure to asbestos-contaminated vermiculite by conducting a series of tests to evaluate the extent of the risk. The EPA investigation concluded that the potential exposure to asbestos from some vermiculite products poses only a minimal health risk to consumers. The EPA recommended that consumers reduce the low risk associated with the occasional use of vermiculite during gardening activities by limiting the amount of dust produced during use. Specifically, the EPA suggested that consumers use vermiculite outdoors or in a well-ventilated area; keep vermiculite damp while using it; avoid bringing dust from vermiculite use into the home on clothing; and use premixed potting soil, which is less likely to generate dust.
The regulations described above and other actions, coupled with widespread public concern about the health hazards of asbestos, have resulted in a significant annual decline in U.S. use of asbestos. Domestic consumption of asbestos amounted to about 803,000 metric tons in 1973, but it had dropped to about 2,400 metric tons by 2005 (3, 5).
What are the health hazards of exposure to asbestos?
People may be exposed to asbestos in their workplace, their communities, or their homes. If products containing asbestos are disturbed, tiny asbestos fibers are released into the air. When asbestos fibers are breathed in, they may get trapped in the lungs and remain there for a long time. Over time, these fibers can accumulate and cause scarring and inflammation, which can affect breathing and lead to serious health problems (6).
Asbestos has been classified as a known human carcinogen (a substance that causes cancer) by the U.S. Department of Health and Human Services, the EPA, and the International Agency for Research on Cancer (2, 3, 7, 8). Studies have shown that exposure to asbestos may increase the risk of lung cancer and mesothelioma (a relatively rare cancer of the thin membranes that line the chest and abdomen). Although rare, mesothelioma is the most common form of cancer associated with asbestos exposure. In addition to lung cancer and mesothelioma, some studies have suggested an association between asbestos exposure and gastrointestinal and colorectal cancers, as well as an elevated risk for cancers of the throat, kidney, esophagus, and gallbladder (3, 4). However, the evidence is inconclusive.
Asbestos exposure may also increase the risk of asbestosis (a chronic lung disease that can cause shortness of breath, coughing, and permanent lung damage) and other nonmalignant lung and pleural disorders, including pleural plaques (changes in the membrane surrounding the lung), pleural thickening, and pleural effusions (abnormal collections of fluid between the thin layers of tissue lining the lung and the wall of the chest cavity). Although pleural plaques are not precursors to lung cancer, evidence suggests that people with pleural disease caused by asbestos exposure may be at increased risk for lung cancer (9).
Who is at risk for an asbestos-related disease?
Everyone is exposed to asbestos at some time during their life. Low levels of asbestos are present in the air, water, and soil. However, most people do not become ill from their exposure. People who become ill from asbestos are usually those who are exposed to it on a regular basis, most often in a job where they work directly with the material or through substantial environmental contact.
Since the early 1940s, millions of American workers have been exposed to asbestos. Health hazards from asbestos fibers have been recognized in workers exposed in shipbuilding trades, asbestos mining and milling, manufacturing of asbestos textiles and other asbestos products, insulation work in the construction and building trades, and a variety of other trades. Demolition workers, drywall removers, asbestos removal workers, firefighters, and automobile workers also may be exposed to asbestos fibers. However, recent studies do not support an increased risk of lung cancer or mesothelioma among automobile mechanics exposed to asbestos through brake repair (10). As a result of Government regulations and improved work practices, today’s workers (those without previous exposure) are likely to face smaller risks than did those exposed in the past.
Those involved in the rescue, recovery, and cleanup at the site of the September 11, 2001, attacks on the World Trade Center (WTC) in New York City are another group at risk of developing an asbestos-related disease. Because asbestos was used in the construction of the North Tower of the WTC, when the building was attacked, hundreds of tons of asbestos were released into the atmosphere. Those at greatest risk include firefighters, police officers, paramedics, construction workers, and volunteers who worked in the rubble at Ground Zero. Others at risk include residents in close proximity to the WTC towers and those who attended schools nearby. These populations will need to be followed to determine the long-term health consequences of their exposure (11).
One study found that nearly 70 percent of WTC rescue and recovery workers suffered new or worsened respiratory symptoms while performing work at the WTC site. The study describes the results of the WTC Worker and Volunteer Medical Screening Program, which was established to identify and characterize possible WTC-related health effects in responders. The study found that about 28 percent of those tested had abnormal lung function tests, and 61 percent of those without previous health problems developed respiratory symptoms (12). However, it is important to note that these symptoms may be related to exposure to debris components other than asbestos.
Although it is clear that health risks from asbestos exposure increase with heavier exposure and longer exposure time, investigators have found asbestos-related diseases in individuals with only brief exposures. Generally, those who develop asbestos-related diseases show no signs of illness for a long time after their first exposure. It can take from 10 to 40 years or more for symptoms of an asbestos-related condition to appear (2).
There is some evidence that family members of workers heavily exposed to asbestos face an increased risk of developing mesothelioma. This risk is thought to result from exposure to asbestos fibers brought into the home on the shoes, clothing, skin, and hair of workers. To decrease these exposures, Federal law regulates work practices to limit the possibility of asbestos being brought home in this way. Some employees may be required to shower and change their clothes before they leave work, store their street clothes in a separate area of the workplace, or wash their work clothes at home separately from other clothes (2).
Cases of mesothelioma have also been seen in individuals without occupational exposure, but who live close to asbestos mines or have been exposed to fibers carried home by family members working with asbestos (6).
What factors affect the risk of developing an asbestos-related disease?
Several factors can help to determine how asbestos exposure affects an individual, including (2, 6):
Dose (how much asbestos an individual was exposed to).
Duration (how long an individual was exposed).
Size, shape, and chemical makeup of asbestos fibers.
Source of exposure.
Individual risk factors, such as smoking and pre-existing lung disease.
Although all forms of asbestos are considered hazardous, different types of asbestos fibers may be associated with different health risks. For example, results of several studies suggest that amphibole forms of asbestos may be more harmful than chrysotile, particularly for mesothelioma risk, because they tend to stay in the lungs for a longer period of time (1, 2). All common commercial types of asbestos have been associated with lung cancer (13).
How does smoking affect risk?
Many studies have shown that the combination of smoking and asbestos exposure is particularly hazardous. Smokers who are also exposed to asbestos have a risk of developing lung cancer that is greater than the individual risks from asbestos and smoking added together (3, 6). There is evidence that quitting smoking will reduce the risk of lung cancer among asbestos-exposed workers (4). Smoking combined with asbestos exposure does not appear to increase the risk of mesothelioma (9). However, people who were exposed to asbestos on the job at any time during their life or who suspect they may have been exposed should not smoke.
How are asbestos-related diseases detected?
Individuals who have been exposed (or suspect they have been exposed) to asbestos fibers on the job, through the environment, or at home via a family contact should inform their doctor of their exposure history, whether or not they experience any symptoms. The symptoms of asbestos-related diseases may not become apparent for many decades after exposure. It is particularly important to check with a doctor if any of the following symptoms develop (6):
Shortness of breath, wheezing, or hoarseness.
A persistent cough that gets worse over time.
Blood in the sputum (fluid) coughed up from the lungs.
Pain or tightening in the chest.
Difficulty swallowing.
Swelling of the neck or face.
Loss of appetite.
Weight loss.
Fatigue or anemia.
A thorough physical examination, including a chest x-ray and lung function tests, may be recommended. The chest x–ray is currently the most common tool used to detect asbestos-related diseases. However, it is important to note that chest x-rays cannot detect asbestos fibers in the lungs, but they can help identify any early signs of lung disease resulting from asbestos exposure (2).
Studies have shown that computed tomography (CT) (a series of detailed pictures of areas inside the body taken from different angles; the pictures are created by a computer linked to an x-ray machine) may be more effective than conventional chest x-rays at detecting asbestos-related lung abnormalities in individuals who have been exposed to asbestos (14).
A lung biopsy, which detects microscopic asbestos fibers in pieces of lung tissue removed by surgery, is the most reliable test to confirm the presence of asbestos-related abnormalities. A bronchoscopy is a less invasive test than a biopsy and detects asbestos fibers in material that is rinsed out of the lungs. It is important to note that these tests cannot determine how much asbestos an individual may have been exposed to or whether disease will develop (14). Asbestos fibers can also be detected in urine, mucus, or feces, but these tests are not reliable for determining how much asbestos may be in an individual’s lungs (2).
How can workers protect themselves from asbestos exposure?
The Occupational Safety and Health Administration (OSHA) is a component of the U.S. Department of Labor (DOL) and is the Federal agency responsible for health and safety regulations in maritime, construction, manufacturing, and service workplaces. OSHA established regulations dealing with asbestos exposure on the job, specifically construction work, shipyards, and general industry, that employers are required to follow. In addition, the Mine Safety and Health Administration (MSHA), another component of the DOL, enforces regulations related to mine safety. Workers should use all protective equipment provided by their employers and follow recommended work practices and safety procedures. For example, National Institute for Occupational Safety and Health (NIOSH)-approved respirators that fit properly should be worn by workers when required.
Workers who are concerned about asbestos exposure in the workplace should discuss the situation with other employees, their employee health and safety representative, and their employers. If necessary, OSHA can provide more information or make an inspection. Regional offices of OSHA are listed in the "United States Government" section of a telephone directory’s blue pages (under "Department of Labor"). Regional offices can also be found at http://www.osha.gov/html/RAmap.html on the Internet.
More information about asbestos is available on the OSHA Asbestos Web page, which has links to information about asbestos in the workplace, including what OSHA standards apply, the hazards of asbestos, evaluating asbestos exposure, and controls used to protect workers. This page is available at http://www.osha.gov/SLTC/asbestos/index.html on the Internet. OSHA’s national office can be contacted at:
Organization:
Office of Public Affairs Occupational Safety and Health Administration U.S. Department of Labor
Address:
Room N–3649200 Constitution Avenue, NW.Washington, DC 20210
Telephone:
202–693–19991–800–321–6742 (1–800–321–OSHA)
TTY (for deaf or hard of hearing callers):
1–877–889–5627
Internet Web site:
http://www.osha.gov/as/opa/worker/index.html (workers’ page)
Mine workers can contact MSHA at:
Organization:
Office of Public AffairsMine Safety and Health Administration U.S. Department of Labor
Address:
21st Floor 1100 Wilson BoulevardArlington, VA 22209
Telephone:
202–693–9400 1–800–746–1554
Internet Web site:
http://www.msha.govhttp://www.msha.gov/codeaphone/codeaphonenew.htm(National Hazard Reporting Page)
The National Institute for Occupational Safety and Health (NIOSH), part of the Centers for Disease Control and Prevention, is another Federal agency that is concerned with asbestos exposure in the workplace. NIOSH conducts asbestos-related research, evaluates work sites for possible health hazards, and makes exposure control recommendations. In addition, NIOSH distributes publications on the health effects of asbestos exposure and can suggest additional sources of information. NIOSH can be contacted at:
Organization:
Education and Information Division Information Resources Branch National Institute for Occupational Safety and Health
Address:
Robert A. Taft Laboratories4676 Columbia ParkwayCincinnati, OH 45226
Telephone:
1–800–356–4674 (1–800–35–NIOSH)
E-mail:
eidtechinfo@cdc.gov
Internet Web site:
http://www.cdc.gov/niosh
What programs are available to help individuals with asbestos-related diseases?
Some people with asbestos-related illness may be eligible for Medicare coverage. Information about benefits is available from Medicare’s Regional Offices, located in 10 major cities across the United States and serving specific geographic areas. The Regional Offices serve as the agency’s initial point of contact for beneficiaries, health care providers, state and local governments, and the general public. Contact information for each Regional Office can be found at http://www.cms.hhs.gov/RegionalOffices on the Internet. General information about Medicare is available by calling toll-free 1–800–633–4227 (1–800–MEDICARE) or visiting http://www.medicare.gov on the Internet.
People with occupational asbestos-related diseases also may qualify for financial help, including medical payments, under state workers’ compensation laws. Because eligibility requirements vary from state to state, workers employed by private companies or by state and local government agencies should contact their state workers’ compensation board. Contact information for state workers’ compensation officials may be found in the blue pages of a local telephone directory or at http://www.dol.gov/esa/regs/compliance/owcp/wc.htm on the Internet.
If exposure occurred during employment with a Federal agency, medical expenses and other compensation may be covered by the Federal Employees’ Compensation Program, which is administered by the DOL, Employment Standards Administration’s Office of Workers’ Compensation Programs. This program provides workers’ compensation benefits to Federal (civilian) employees for employment-related injuries and diseases. Benefits include wage replacement, payment for medical care, and, where necessary, medical and vocational rehabilitation assistance in returning to work. Benefits may also be provided to dependents if the injury or disease causes the employee’s death. The program has 12 district offices nationwide.
In addition, the Longshore and Harbor Workers’ Compensation Program provides benefits to longshoremen, harbor workers, other maritime workers, and other classes of private industry workers who are injured during the course of employment or suffer from diseases caused or worsened by conditions of employment. Information about eligibility and how to file a claim for benefits under either of these programs is available from:
Organization:
Office of Workers’ Compensation ProgramsEmployment Standards AdministrationU.S. Department of Labor
Address:
Frances Perkins Building200 Constitution Avenue, NW.Washington, DC 20210
Telephone:
1–866–692–7487 (1–866–OWCPIVR)202–693–0040 (Federal Employees’ Compensation Program)202–693–0038 (Longshore and Harbor Workers’ Compensation Program)
E-mail:
OWCP-Public@dol.gov
Internet Web site:
http://www.dol.gov/esa/owcp_org.htm
Eligible veterans may receive health care at a Department of Veterans Affairs (VA) Medical Center for an asbestos-related disease. Veterans can receive treatment for service-connected and nonservice-connected medical conditions. Information about eligibility and benefits is available from the VA Health Benefits Service Center at 1–877–222–8387 (1–877–222–VETS) or on the VA Web site at http://www1.va.gov/health on the Internet.
Is there legislation to help victims of asbestos-related health diseases?
No Federal legislation has been enacted yet to compensate victims of asbestos-related diseases or to protect people from asbestos exposure. However, in 2005, the Fairness in Asbestos Injury Resolution (FAIR) Act (Senate bill 852) was introduced into Congress (15). This bill would create a national trust fund to compensate victims suffering from asbestos-related diseases. The proposed trust fund would be administered by the DOL, outside of the courts, through a claims process whereby all those with certain medical symptoms and evidence of asbestos-related disease would be compensated. Funding for the trust would come from insurance companies and companies that mined, manufactured, and sold asbestos or asbestos products. Under the bill, individuals affected by asbestos exposure would no longer be able to pursue awards for damages in any Federal or state court.
What other organizations offer information related to asbestos exposure?
The organizations listed below can provide more information about asbestos exposure.
The Agency for Toxic Substances and Disease Registry (ATSDR) is the principal Federal agency responsible for evaluating the human health effects of exposure to hazardous substances. The agency works in close collaboration with local, state, and other Federal agencies, with tribal governments, and with communities and local health care providers to help prevent or reduce harmful human health effects from exposure to hazardous substances. The ATSDR provides information about asbestos and where to find occupational and environmental health clinics. The ATSDR can be contacted at:
Organization:
Agency for Toxic Substances and Disease Registry
Address:
1825 Century BoulevardAtlanta, GA 30345
Telephone:
1–800–232–4636 (1–800–CDC–INFO)
TTY:
1-888-232-6348
E-mail:
cdcinfo@cdc.gov
Internet Web site:
http://www.atsdr.cdc.gov
The U.S. Environmental Protection Agency (EPA) regulates the general public’s exposure to asbestos in buildings, drinking water, and the environment. The EPA offers a Toxic Substances Control Act (TSCA) Hotline and an Asbestos Ombudsman. The TSCA Hotline provides technical assistance and information about asbestos programs implemented under the TSCA, which include the Asbestos School Hazard Abatement Act and the Asbestos Hazard Emergency Response Act. The Asbestos Ombudsman focuses on asbestos in schools and handles questions and complaints. Both the TSCA Hotline and the Asbestos Ombudsman can provide publications on a number of topics, particularly on controlling asbestos exposure in schools and other buildings. The Ombudsman operates a toll-free hotline for small businesses, trade associations, and others seeking free, confidential help.
The EPA Web site includes a list of EPA regional and state asbestos contacts at http://www.epa.gov/asbestos/pubs/regioncontact.html on the Internet. In addition, EPA’s Asbestos and Vermiculite home page provides information about asbestos and its health effects and links to asbestos resources, including suggestions for homeowners who suspect asbestos in their homes, and laws and regulations applicable to asbestos. This page can be found at http://www.epa.gov/asbestos/ on the Internet. Questions may be directed to:
Organization:
U.S. Environmental Protection AgencyEPA West Building National Program Chemicals Division
Address:
Mail Code 7404T 1200 Pennsylvania Avenue, NW.Washington, DC 20460
TSCA Hotline:
202–554–1404
TTY:
202–554–0551
Asbestos Ombudsman:
1–800–368–5888
E-mail:
tsca-hotline@epa.gov
Internet Web site:
http://www.epa.gov/asbestos/
Another EPA resource that may be of interest is the brochure titled Current Best Practices for Preventing Asbestos Exposure Among Brake and Clutch Repair Workers. Released in April 2007, this brochure includes work practices for both automotive professionals and home mechanics that may be used to avoid asbestos exposure. It also summarizes existing OSHA regulatory requirements for professional auto mechanics. The brochure supersedes the EPA’s existing Guidance for Preventing Asbestos Disease Among Auto Mechanics, which is known as the "Gold Book." The brochure can be found at http://www.epa.gov/asbestos/pubs/brakesbrochure.html on the Internet.
The U.S. Consumer Product Safety Commission (CPSC) is responsible for protecting the public from unreasonable risks of serious injury or death from more than 15,000 types of consumer products, including asbestos, under the agency’s jurisdiction. The CPSC maintains a toll-free 24-hour hotline where callers can obtain product safety and other agency information and report unsafe products. In addition, CPSC publications provide guidelines for repairing and removing asbestos, and general information about asbestos in the home. CPSC can be contacted at:
Organization:
Office of Information and Public Affairs U.S. Consumer Product Safety Commission
Address:
4330 East West HighwayBethesda, MD 20814
Telephone:
1–800–638–2772
TTY (for deaf or hard of hearing callers):
1–800–638–8270
E-mail:
info@cpsc.gov
Internet Web site:
http://www.cpsc.gov
Individuals can also contact their local or state health department with questions or concerns about asbestos.
Information about cancer is available by calling the National Cancer Institute’s (NCI) Cancer Information Service (CIS) at 1–800–4–CANCER (1–800–422–6237) or by visiting the NCI’s Web site at http://www.cancer.gov on the Internet. The NCI is a component of the National Institutes of Health. Information about quitting smoking, including smoking cessation counseling, is available by calling the NCI’s Smoking Quitline toll-free at 1–800–44U–QUIT (1–800–448–7848) or visiting the NCI’s smoking cessation Web site at http://www.smokefree.gov on the Internet.
Selected References
Agency for Toxic Substances and Disease Registry (April 2006). What Is Asbestos? Retrieved August 30, 2006, from: http://www.atsdr.cdc.gov/asbestos/more_about_asbestos/what_is_asbestos.
Agency for Toxic Substances and Disease Registry (September 2001). Public Health Statement for Asbestos. Retrieved August 30, 2006, from: http://www.atsdr.cdc.gov/toxprofiles/phs61.html.
National Toxicology Program. Report on Carcinogens. Eleventh Edition. U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005.
Ullrich RL. Etiology of cancer: Physical factors. In: DeVita VT Jr., Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Vol. 1 and 2. 7th ed. Philadelphia: Lippincott Williams and Wilkins, 2004.
Virta RL (January 2006). Mineral Commodity Summaries: Asbestos. U.S. Geological Survey Minerals Information. Retrieved August 30, 2006, from: http://minerals.usgs.gov/minerals/pubs/commodity/asbestos/asbesmcs06.pdf.
Agency for Toxic Substances and Disease Registry (June 2006). Asbestos: Health Effects. Retrieved August 30, 2006, from: http://www.atsdr.cdc.gov/asbestos/asbestos/health_effects/index.html.
U.S. Environmental Protection Agency. Health Effects Assessment for Asbestos. U.S. Environmental Protection Agency, 1984. EPA/540/1-86/049 (NTIS PB86134608).
International Agency for Research on Cancer (March 1998). Asbestos. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 14. Lyon, France: Retrieved September 6, 2006, from: http://monographs.iarc.fr/ENG/Monographs/vol14/volume14.pdf.
Agency for Toxic Substances and Disease Registry (November 2000). Case Studies in Environmental Medicine: Asbestos Toxicity. Retrieved September 6, 2006, from: http://www.atsdr.cdc.gov/HEC/CSEM/asbestos/index.html.
Laden F, Stampfer MJ, Walker AM. Lung cancer and mesothelioma among male automobile mechanics: A review. Reviews on Environmental Health 2004; 19(1):39–61.
Landrigan PJ, Lioy PJ, Thurston G, et al. Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 2004; 112(6):731–739.
Herbert R, Moline J, Skloot G, et al. The World Trade Center disaster and the health of workers: Five-year assessment of a unique medical screening program. Environmental Health Perspectives 2006; 114(12):1853–1858.
Schrump DS, Altorki NK, Henschke CL, et al. Non-small cell lung cancer. Cancer of the lung. In: DeVita VT Jr., Hellman S, Rosenberg SA, editors. Principles and Practice of Oncology. Vol. 1 and 2. 7th ed. Philadelphia: Lippincott Williams and Wilkins, 2004.
Agency for Toxic Substances and Disease Registry (June 2006). Asbestos: Working with Patients: Diagnosis. Retrieved August 30, 2006, from: http://www.atsdr.cdc.gov/asbestos/medical_community/working_with_patients.
U.S. Congressional Budget Office (August 2005). Congressional Budget Office Cost Estimate for S. 852, Fairness in Asbestos Injury Resolution Act of 2005. Retrieved August 30, 2006, from: http://www.cbo.gov/ftpdocs/68xx/doc6881/s852.pdf.

mesothelioma symptoms

Mesothelioma is a unique disease in that symptoms do not usually manifest themselves until anywhere from 20 to 50 years after exposure to asbestos. For patients and doctors, this is the most frustrating aspect of the disease. The latency period of mesothelioma is lengthy, making the disease undiagnosable until its later stages when symptoms finally begin to appear and little can be done to slow the progress of the disease.
Recognizing Symptoms
Just like any other disease, the symptoms of mesothelioma vary from case to case and with the severity of the illness. The type of mesothelioma - whether pleural, peritoneal, or pericardial - also determines what the symptoms might be. Often times, the general overall health of the individual, as well as his/her age, may also play a role in how the patient is affected by the disease and which symptoms are most bothersome.
One of the most difficult problems with diagnosing mesothelioma and connecting the symptoms with the disease is the fact that so many of the symptoms - both individually and in tandem - can easily be mistaken for other more common diseases like flu, pneumonia, bronchitis, heart disease, and others.
A doctor well versed in mesothelioma treatment will take time to investigate a patient's history and hopefully connect past exposure to asbestos with the symptoms. Patients, however, can do their part as well. Anyone that was ever exposed to asbestos, even if it was decades ago, should inform their doctor of the exposure. That information will not only aid the doctor in diagnosis but will also help eliminate the need for many costly and uncomfortable tests that may be ordered while fishing for a diagnosis.
Tests are being developed that will help diagnose mesothelioma at an earlier stage, even before the most common symptoms appear. It is hoped that these tests will aid in treating the disease before it reaches its most advanced stages.

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baines and ernst

Baines & Ernst are the biggest Debt management company in the UK.
Impressive huh? One of my mates enlisted their help as he found himself in a situation where his sleep was affected, he worried constantly, he had used all his credit cards to the limit and got loans to have a nice life...It all started when his long term partner ditched him for a bloke with more money and a better job, but hey thats another story...
He felt down and wanted to cheer himself up and he had 2 credit cards with £1000 on each to spend...Clothes quickly ensured he reached his limit and he called up for a higher limit and got it, he applied online at night for further credit cards and got them...he had a decent job...holidays added to the cards and the new ones quickly reached limits and even got extended...he never missed a payment..
Overall in 2 years he had £18,000 in credit to 4 major companies, names withheld...He kept going out to dinner with every girl he met to impress and thus his ready cash was spent every month, he stopped a few payments here and there to allow him the payments to be used as cash...
He decided to change jobs and in doing so managed to have a period in his life where 2 months he would have little cash flow...and the proverbial hit the fan in a big way...The letters started coming in and he placed them neatly in the bin...worst mistake...
when he got paid again he decided to treat himself again to cheer himself up...Sleep was now becomning an issue and he would call friends at all times of the day and night, his work was affected as he was thinking about his debt...pressure made him ill for a few weeks...sick pay made his salary even lower and less chance of paying any creditors that month too...
Then he bought a tabloid one day and noticed the advert for Baines and Ernst...His problems then started after months of confidence with B&E....A debt management company exists essentially to as the title says manage debt, which means that they negotiate a lower monthly payment figure with your creditors, they ensure that the mortgage is paid firstly and everyone is given a percentage of your income which you can afford to give..
The money you can give is all calculated out with your earnings and outgoings/allowances...They in the majority of cases contact your creditors and deal with them directly and you just sit back and relax...and B&E create Voluntary arrangements with your creditors which means they tell a creditor you are having trouble and will pay them a set amount from the B&E account you have set up...
You pay B&E an agreed amount which is then divided to the creditors and a monthly fee to B&E for their trouble...Here is some figures you may find interesting :
For a £397 payment per month for a debt of £18,000...creditors with varying amounts and interest rates, he had one creditor who after interest was calculated every month he effectively paid £10 to the account...think how many years £3000 would take to pay off...Of the 4 creditors he had the total he paid to them was £300...for a £18000 debt, cool or what? If you got a good memory you would notice that he paid £397...Yep £97 every month as a fee to B&E, how many months was it taking to pay off? I worked it out with him and gave up after 10 Years...interest was still to be paid...
So after looking at the figures a few months after enlisting B&E's help he realised that he was in a further spiral, he was not allowed any further debt whilst with B&E, his first payment of £397 would be lost if he withdrew from the programme, his creditors could decide at any time that they were not happy with the arrangement and indeed he started getting a letter from one of his creditors telling him they did not wish to deal with B&E and that Legal action would be taken against him...he passed the letters to B&E as agreed but they kept coming every month although he paid his £397...His credit status seemed to be in a state which would never be repaired...So what made him join Baines & Ernst?
The advert stated :One fixed monthly payment to cover all your debts, Solve your debt regardless of credit status, stop worrying about your debt, reduce payments by up to 75% per month...giving you cash to spend on living expenses...Not a loan or bankruptcy...
So he was hooked, and when he realised that he could have done all the things Baines and Ernst do himself and saved the £97 per month and given it to his creditors he was very unhappy which is when he told me of his problems...What can you do?
Well if you contact your creditors yourself it shows them you are living up to your problems and that you want to pay them...they ARE very understanding if you contact them directly...The local citizens advice bureau gives free advice on this problem, which give you best advice and not what would make them the most money...
The main thing you need to do is face up to your problems and speak to someone, whether it be a friend or family member they can and will think objectively for you without being bogged down with depression on the amounts you owe...After paying for just over a year he stopped paying B&E and spoke to his creditors directly, most accepted the same payments and he had an extra £97 to go round them every month, true he did lose his initial payment of £397 but he has now sorted out himself and is working in a positive manner to pay of his debts...
Baines and Ernst state they satisy 9 out of 10 clients...so maybe some have better figures that I have not seen...Last week he told me that he got a letter from B&E telling him that he qualified for a Trust deed to be set up...Why was this not the initial solution to his debt problem?
This involves a payment of around £200 into a trust and after 3 years the debt is written off and is legally binding if 75% of the creditors agree...he is going to contact them again...How much more money can they make from him? Answers on a postcard please...Did you know that Baines and Ernst were prosecuted this year for using MIcrosoft Office which was without a licence and they have appeared on the BBC watchdog programme

home equity loans

A home equity loan (sometimes abbreviated HEL) is a type of loan in which the borrower uses the equity in their home as collateral. These loans are sometimes useful to help finance major home repairs, medical bills or college education. A home equity loan creates a lien against the borrower's house, and reduces actual home equity.
Home equity loans are most commonly second position liens (second trust deed), although they can be held in first or, less commonly, third position. Most home equity loans require good to excellent credit history, and reasonable loan-to-value and combined loan-to-value ratios. Home equity loans come in two types, closed end and open end.
Both are usually referred to as second mortgages, because they are secured against the value of the property, just like a traditional mortgage. Home equity loans and lines of credit are usually, but not always, for a shorter term than first mortgages. In the United States, it is sometimes possible to deduct home equity loan interest on one's personal income taxes.
There is a specific difference between a home equity loan and a Home Equity Line of Credit (HELOC). A HELOC is a line of revolving credit with an adjustable interest rate whereas a home equity loan is a one time lump-sum loan, often with a fixed interest rate.

Mesothelioma Diagnosis111

Because mesothelioma's symptoms are not unique to it and the disease's relative rarity, cases of mesothelioma misdiagnosed are not uncommon. A review of the patient's medical history is an important part in assessing the risk of mesothelioma.
Mesothelioma: Diagnosis and Differentiation Journal Articles
07.10.08 - Localized malignant mesothelioma in the middle mediastinum: Report of a case
Surgery Today. 2008;38(7):635-8. Epub 2008 Jul 9. [Link] Akamoto S, Ono Y, Ota K, Suzaki N, Sasaki A, Matsuo Y, Hayashi K. Department of Surgery, Jyuzen General Hospital, Ehime, Japan. Abstract Localized malignant mesothelioma in the mediastinum is rare and most known cases have been reported as ?localized malignant pericardial mesothelioma.? We report a case of a [...]
07.09.08 - Immunohistochemistry of pulmonary and pleural neoplasia
Archives of Pathology and Laboratory Medicine. 2008 Jul;132(7):1062-72. [Link] Beasley MB. Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA. mbbeasleymd@yahoo.com Abstract Context: The use of immunohistochemical stains has several applications in the evaluation of pulmonary and pleural neoplasms. The number of available immunohistochemical stains is continually expanding and, although these stains are an important [...]
07.09.08 - Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children?s hospital
Archives of Pathology and Laboratory Medicine. 2008 Jul;132(7):1079-103. [Link] Dishop MK, Kuruvilla S. Department of Pathology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA. mkdishop@texaschildrenshospital.org Abstract Context: Primary lung neoplasms are rare in children, but they comprise a broad and interesting spectrum of lesions, some of which are familiar from other tissue sites, and some [...]
07.09.08 - Pulmonary sarcomatous tumors
Archives of Pathology and Laboratory Medicine. 2008 Jul;132(7):1104-17. [Link] Litzky LA. Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4283, USA. lalitzky@mail.med.upenn.edu Abstract Context: Sarcomatous pulmonary neoplasms are a rare and diagnostically challenging group of tumors. Primary pulmonary sarcomas must be distinguished from the more frequent occurrence of sarcoma metastatic to the lung, [...]
07.09.08 - Primary pleural neoplasia: entities other than diffuse malignant mesothelioma
Archives of Pathology and Laboratory Medicine. Vol. 132, No. 7, pp. 1149?1170. [Link] Guinee DG, Allen TC. Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA. Abstract Context: Overwhelmingly, the most common neoplasm involving the pleura is metastatic carcinoma. In contrast, diffuse malignant mesothelioma occurs relatively rarely; however, it is nonetheless the most common neoplasm primary to [...]
As a first step in diagnosing the disease, the doctor may order an x-ray of the chest or abdomen or a CT (or CAT) scan or MRI may be performed. Although mesothelioma typically cannot be seen on an x-ray, the tumor often causes a pleural effusion, or fluid collection between the lung and chest wall. This abnormal finding is associated with shortness of breath and warrants clinical follow up. Lung function tests may also be completed.
The doctor may look inside the chest cavity with a special instrument called a thoracoscope. A cut will be made through the chest wall and the thoracoscope will be put into the chest between two ribs. This test, called thoracoscopy, is usually done in the hospital. Before the test, the patient will be given a local anesthetic (a drug that causes a loss of feeling for a short period of time). Some pressure may be felt, but usually there is no pain.
The doctor may also look inside the abdomen (peritoneoscopy) with a special tool called a peritoneoscope. The peritoneoscope is put into an opening made in the abdomen. This test is also usually done in the hospital. Before the test is done, a local anesthetic will be given.
If tissue that is not normal is found, the doctor will need to cut out a small piece and have it reviewed under a microscope to see if there are any cancer cells. This is called a biopsy. Biopsies are usually done during the thoracoscopy or peritoneoscopy.
Diagnosing mesothelioma is very difficult, and cases of mesothelioma misdiagnosed are unfortunately not uncommon. It is important to share your case history of work experience (especially in shipyards and at construction sites) and asbestos exposure potential with your physicians if you feel mesothelioma is a risk. Asbestos fibres can also be carried into the home on clothing, inadvertently exposing the deadly fibres, and the risk of mesothelioma, to family members.
A mesothelioma diagnosis is serious, but treatments are available. The chance of recovery (prognosis) depends on the size of the cancer, where the cancer is, how far the cancer has spread, how the cancer cells look under the microscope, how the cancer responds to treatment, and the patient's age. As with most types of cancer, early diagnosis is an excellent first step in fighting the disease.

mesothelioma diagnosis

Mesothelioma is not always diagnosed because the cancer is still unrecognizable. A mesothelioma diagnosis may often be classified as another condition because the symptoms are similar to those of other illnesses. Even today, a mesothelioma diagnosis can be classified as lung cancer, which is an entirely different disease. Mesothelioma is a cancer of the lining of the chest, lung, and abdominal cavity and has been linked to high levels of workplace and non-occupational exposure to asbestos.
A mesothelioma diagnosis most commonly begins with a complete medical history review and physical examination of a patient who suffers from mesothelioma symptoms and signs including shortness of breath, chest pains, swollen abdomen, and more. The physical exam should involve a number of imaging tests to search for suspicious cell formation. These tests may include:
X-rays Chest or abdomen x-rays can reveal fluid build-up, masses, or signs of non-cancerous pleural disease .
Computed Tomography (CT) Scan A series of detailed images of the body. CT scans can locate pleural disease, chest wall invasions, and can guide fine needle aspiration tests. However, CT scans cannot differentiate between benign or malignant mesothelioma.
Magnetic Resonance Imaging (MRI) MRI scans use a computer-linked magnet to photograph details of the inside of the body and can determine the severity of a tumor.
Positron Emission Tomography (PET) PET imaging tests have become one of the most efficient ways of diagnosing mesothelioma tumors as well as determining the staging of the cancer.
Biopsy A needle biopsy is almost always necessary to confirm a mesothelioma diagnosis. In a biopsy, a sample of tissue is removed and examined under a microscope to test for cancer cells. Depending on the location of the abnormal area, a biopsy can be done in different ways including:
Thoracoscopy - If the cancer is located in the pleura, a small incision will be made through the chest wall and a thoracoscope will be inserted to obtain a tissue sample.
Peritoneoscopy If the cancer is in the abdominal cavity, a doctor will use a peritoneoscope to obtain sample tissue for further examination.
If you or a loved one experience any symptoms of mesothelioma, it is important to seek immediate medical attention.
Please contact us today to learn more information about mesothelioma diagnosis or to speak with a qualified and experienced mesothelioma attorney who will protect your legal rights and interests.

SEARCH ENGINE OPTIMIZATION (SEO)

Initial Consultation & Keywords
Our technical staff begins by checking the current status of your website to ensure that the optimization process will not be encumbered by any unforeseen problems. One of our staff optimizers will then use manual searches and custom research software to gather data and create a list of the most trafficked and targeted keywords in your industry. Your optimizer will consult with you to choose the best keywords for your optimization.
Content Creation After a list of keywords has been finalized for your website, it is passed along to our content writers. Using their training and experience, our writers will create original, unique content or revise your current site copy. Keywords will be placed in accordance with proper SEO densities while maintaining a professional copy style that is appropriate for site marketing and human readers, not just search engine “spiders.” Our writers will contact you before getting started on your content to ensure that the essence of your website is not compromised.
Website Redevelopment Our optimization engineers will redevelop your website to seamlessly integrate the optimized content and effectively communicate your keywords to search engines. All aspects of the website – including its architecture, meta tags, alt tags, graphic text, internal link structure and subpages – will be modified to be spider friendly and to ethically meet the keyword relevancy requirements of the search engines’ algorithms. The staff of Submit Express is dedicated to maintaining the design integrity and essence of your website.
Link Development The development of incoming links from well-established websites is one of the major variables in attaining high search engine rankings. Link development is absolutely essential to your website’s success and is a major part of the optimization service that we offer. A high quantity of quality links can be developed through a variety of means, including:• One-way links from directories and other related sites • Reciprocal link exchanges with related sites• Fee-based directory submissions • Targeted link buys
Submission After the optimization process is complete, we will submit your website to all the major search engines and directories, including Yahoo, AltaVista, HotBot, AlltheWeb, Google, AOL, iWon, Netscape, MSN, Lycos, Teoma, Ask and DMOZ (Open Directory). In addition to these submissions, we add fee-based directories such as Yahoo Directory, LookSmart and several other quality directories which will add to your link popularity. Lastly, if your website has indexing issues, we will create and submit site maps to both Google and Yahoo via their respective programs.
Reporting Before we start the optimization process, we will run a ranking report to determine where your website ranks with the various search engines. We will also send you the report so you can see the results. Once optimization is complete, we will run monthly reports to check on your website's progress. You will be updated with these monthly ranking report results via e-mail. In addition to the monthly ranking reports, our staff will run weekly search engine monitoring to verify that your site has not been dropped by any of the major search engines. To ensure your satisfaction, our technicians will periodically call you or email you just to check in. We also invite you to call our staff anytime with questions.

Definition

Lung cancer is the leading cause of cancer deaths in the United States, among both men and women. It claims more lives each year than colon, prostate, lymph and breast cancers combined.
Yet most lung cancer deaths could be prevented. That's because smoking accounts for nearly 90 percent of lung cancer cases. Your risk of lung cancer increases with the length of time and number of cigarettes you smoke. If you quit smoking, even after smoking for many years, you can significantly reduce your chances of developing lung cancer. Protecting yourself from other risk factors for lung cancer, such as exposure to asbestos, radon and secondhand smoke, also decreases your risk.

lung cancer

Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. This growth may lead to metastasis, invasion of adjacent tissue and infiltration beyond the lungs. The vast majority of primary lung cancers are carcinomas of the lung, derived from epithelial cells. Lung cancer, the most common cause of cancer-related death in men and the second most common in women,[1][2] is responsible for 1.3 million deaths worldwide annually.[3] In the UK, it is the most common site of fatal cancer in both men and women. The most common symptoms are shortness of breath, coughing (including coughing up blood), and weight loss.[4]
The main types of lung cancer are small cell lung carcinoma and non-small cell lung carcinoma. This distinction is important because the treatment varies; non-small cell lung carcinoma (NSCLC) is sometimes treated with surgery, while small cell lung carcinoma (SCLC) usually responds better to chemotherapy and radiation.[5] The most common cause of lung cancer is long term exposure to tobacco smoke.[6] The occurrence of lung cancer in non-smokers, who account for as many as 20% of cases, often attributed to a combination of genetic factors,[7][8] radon gas,[9] asbestos,[10] and air pollution,[11][12][13] including second-hand smoke.[14][15]
Lung cancer may be seen on chest x-ray and computed tomography (CT scan). The diagnosis is confirmed with a biopsy. This is usually performed via bronchoscopy or CT-guided biopsy. Treatment and prognosis depend upon the histological type of cancer, the stage (degree of spread), and the patient's performance status. Possible treatments include surgery, chemotherapy, and radiotherapy. With treatment, the five-year survival rate is 14%.[4